The most common and most likely answer to this crossword clue is the 8 letter word PROSTATE
I've seen this crossword clue in The Daily Telegraph
P
R
O
S
T
A
T
E
More clues leading to the result PROSTATE
- Men Only organ writing about article in Times
- Completely exhausted, having lost essential part of thyroid gland
- Gland inclined to Erastianism?
- Organ’s flat missing top of register
- Organ in favour of the government
- Gland that’s prone to lose resistance
- Organ is in favour of country
- ... for say men’s organ
- Like a government supporter's organ
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PROSTATE mean?
PROSTATE noun- The prostate gland.
- Of or relating to the prostate gland.
- Favoring the government, or favoring the government of a state as opposed to a federal government.