Cryptic crossword clue
Gloomy studies makes one blue 7

The most common and most likely answer to this crossword clue is the 7 letter word SADDENS

I've seen this crossword clue in Financial Times
S
A
D
D
E
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S

Buddy explains!

The straight part
We know that "makes one blue" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case makes one blue = saddens.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SADDENS mean?

SADDENS verb
  1. To make sad or unhappy.
  2. To become sad or unhappy.
  3. To darken a color during dyeing.
  4. To render heavy or cohesive.

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