The most common and most likely answer to this crossword clue is the 7 plus 6 letter word KNOWING GLANCE
K
N
O
W
I
N
G
G
L
A
N
C
E
Buddy explains!
The straight part
We know that "a look that he is informed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a look that he is informed = knowing glance.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.