The most common and most likely answer to this crossword clue is the 3 plus 3 letter word WIG OUT
W
I
G
O
U
T
Buddy explains!
The straight part
We know that "Go crazy in US" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case go crazy in us = wig out.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.