Cryptic crossword clue
Going west in Spain, St Anthony’s cross with warning from Rome to move away from danger 8

The most common and most likely answer to this crossword clue is the 8 letter word EVACUATE

E
V
A
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U
A
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E


Buddy explains!

The straight part
We know that "move away from danger" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case move away from danger = evacuate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EVACUATE mean?

EVACUATE verb
  1. To leave or withdraw from; to quit; to retire from
  2. To cause to leave or withdraw from.
  3. To make empty; to empty out; to remove the contents of, including to create a vacuum.
  4. To make empty; to deprive.
  5. To remove; to eject; to void; to discharge, as the contents of a vessel, or of the bowels.
  6. To make void; to nullify; to vacate.

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