Cryptic crossword clue
Goitre — lack of Iodine may lead to this disease 5

The most common and most likely answer to this crossword clue is the 5 letter word ERGOT

E
R
G
O
T

Buddy explains!

The straight part
We know that "disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disease = ergot.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ERGOT mean?

ERGOT noun
  1. Any fungus in the genus Claviceps which are parasitic on grasses.
  2. The sclerotium (wintering stage) of certain fungi in the genus Claviceps, appearing as a deformed grain in certain cereals and grasses infected by the fungi.

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