Cryptic crossword clue
Gone about fighting as an OTT response 12

The most common and most likely answer to this crossword clue is the 12 letter word OVERREACTION

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "an OTT response" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case an ott response = overreaction.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OVERREACTION mean?

OVERREACTION noun
  1. A reaction that is excessive.

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