The most common and most likely answer to this crossword clue is the 5 letter word GENOA
G
E
N
O
A
More clues leading to the result GENOA
- Sail east then north into former colony
- Some knocked back tea — one guzzled port
- Gone around a port in Italy
- Sail for port
- American working for one over in Italian port
- German put up excellent sail
- Information primarily about storing old port
- Hoisted a single good sail
- Home of St Catherine, they say: d’you know her?
- Information on unprotected road in port
Buddy explains!

The straight part
We know that "port in Italy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case port in italy = genoa.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GENOA mean?
GENOA noun- A staysail that resembles a jib but extends aft beyond the mast.
- Genoa cake