Cryptic crossword clue
Good boy, not completely thick, cheers up 8

The most common and most likely answer to this crossword clue is the 8 letter word GLADDENS

I've seen this crossword clue in The Daily Telegraph
G
L
A
D
D
E
N
S

Buddy explains!

The straight part
We know that "cheers up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cheers up = gladdens.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GLADDENS mean?

GLADDENS verb
  1. To cause (something) to become more glad.
  2. To become more glad in one's disposition.

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