The most common and most likely answer to this crossword clue is the 7 letter word MISFITS
I've seen this crossword clue in The Times
M
I
S
F
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T
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More clues leading to the result MISFITS
Buddy explains!

The straight part
We know that "weirdos" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case weirdos = misfits.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MISFITS mean?
MISFITS noun- An ill-fitting garment.
- A failure to fit well; unsuitability, disparity.
- A badly adjusted person; someone unsuitable or set apart because of their habits, behaviour etc.
- To fit badly.