Cryptic crossword clue
Gorbachev’s first lass not affected by his policy 8

The most common and most likely answer to this crossword clue is the 8 letter word GLASNOST

I've seen this crossword clue in The Guardian
G
L
A
S
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The straight part
We know that "his policy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case his policy = glasnost.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GLASNOST mean?

GLASNOST noun
  1. 1980s and early 1990s policy of the Soviet Union under Gorbachev to allow more government transparency; often paired with perestroika

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