The most common and most likely answer to this crossword clue is the 5 letter word DRUGS
I've seen this crossword clue in The Times
D
R
U
G
S
Buddy explains!
The straight part
We know that "Bacardi and Coke?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bacardi and coke? = drugs.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DRUGS mean?
DRUGS noun- A substance used to treat an illness, relieve a symptom, or modify a chemical process in the body for a specific purpose.
- A psychoactive substance, especially one which is illegal and addictive, ingested for recreational use, such as cocaine.
- Anything, such as a substance, emotion or action, to which one is addicted.
- Any commodity that lies on hand, or is not salable; an article of slow sale, or in no demand.
- To administer intoxicating drugs to, generally without the recipient's knowledge or consent.
- To add intoxicating drugs to with the intention of drugging someone.
- To prescribe or administer drugs or medicines.
- A drudge.