Cryptic crossword clue
Gradual acceptance to mind big, second sister 7

The most common and most likely answer to this crossword clue is the 7 letter word OSMOSIS

I've seen this crossword clue in The Guardian
O
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Buddy explains!

The straight part
We know that "Gradual acceptance" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gradual acceptance = osmosis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OSMOSIS mean?

OSMOSIS noun
  1. The net movement of solvent molecules, usually water, from a region of lower solute concentration to a region of higher solute concentration through a partially permeable membrane.
  2. Picking up knowledge accidentally, without actually seeking that particular knowledge.

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