Cryptic crossword clue
Grand and stately feature of the Thames going upstream worries 5

The most common and most likely answer to this crossword clue is the 5 letter word GNAWS

G
N
A
W
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GNAWS mean?

GNAWS verb
  1. To bite something persistently, especially something tough.
  2. To produce excessive anxiety or worry.
  3. To corrode; to fret away; to waste.

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