Cryptic crossword clue
Grave disease consuming old man

The most common and most likely answer to this crossword clue is the 4 letter word TOMB

I've seen this crossword clue in The Guardian
T
O
M
B


Buddy explains!

The straight part
We know that "Grave" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case grave = tomb.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TOMB mean?

TOMB noun
  1. A small building (or "vault") for the remains of the dead, with walls, a roof, and (if it is to be used for more than one corpse) a door. It may be partly or wholly in the ground (except for its entrance) in a cemetery, or it may be inside a church proper or in its crypt. Single tombs may be permanently sealed; those for families (or other groups) have doors for access whenever needed.
  2. A pit in which the dead body of a human being is deposited; a grave.
  3. One who keeps secrets.
TOMB verb
  1. To bury.

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