Cryptic crossword clue
Great city almost destroyed by drug, surely top killers, perhaps 10

The most common and most likely answer to this crossword clue is the 10 letter word CIGARETTES

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Buddy explains!

The straight part
We know that "killers, perhaps" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case killers, perhaps = cigarettes.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CIGARETTES mean?

CIGARETTES noun
  1. Tobacco or other substances, in a thin roll wrapped with paper, intended to be smoked.
CIGARETTES verb
  1. To give someone a cigarette, and/or to light one for them.

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