Cryptic crossword clue
Greedy-guts having full monty in up-and-coming place could be a barrier to culinary inspiration! 10

The most common and most likely answer to this crossword clue is the 10 letter word EPIGLOTTIS

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Buddy explains!

The straight part
We know that "a barrier to culinary inspiration!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a barrier to culinary inspiration! = epiglottis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EPIGLOTTIS mean?

EPIGLOTTIS noun
  1. A cartilaginous organ in the throat of terrestrial vertebrates covering the glottis when swallowing to prevent food and liquid from entering the trachea, and in Homo sapiens also a speech organ.

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