Cryptic crossword clue
Growth more than once of old college irrational 6

The most common and most likely answer to this crossword clue is the 6 letter word POLYPI

P
O
L
Y
P
I

Buddy explains!

The straight part
We know that "Growth more than once" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case growth more than once = polypi.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POLYPI mean?

POLYPI noun
  1. A cardiac thrombus usually found post-mortem.
  2. An octopus.

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