Cryptic crossword clue
Growth occurring in thyroid, rarely enlarged initially 6

The most common and most likely answer to this crossword clue is the 6 letter word GOITRE

I've seen this crossword clue in The Daily Telegraph
G
O
I
T
R
E


Buddy explains!

The straight part
We know that "Growth occurring in thyroid, rarely enlarged initially" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case growth occurring in thyroid, rarely enlarged initially = goitre.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GOITRE mean?

GOITRE noun
  1. An enlargement of the front and sides of the neck caused by inflammation of the thyroid gland.

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