Cryptic crossword clue
Guarantee Peru’s neutrality will hold up 6

The most common and most likely answer to this crossword clue is the 6 letter word ENSURE

I've seen this crossword clue in The Times
E
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The straight part
We know that "Guarantee" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guarantee = ensure.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENSURE mean?

ENSURE verb
  1. To make a pledge to (someone); to promise, guarantee (someone of something); to assure.
  2. To make sure or certain of something (usually some future event or condition).

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