Cryptic crossword clue
Guard’s folly, regularly missing provocative pest 6

The most common and most likely answer to this crossword clue is the 6 letter word GADFLY

I've seen this crossword clue in Independent
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What does GADFLY mean?

GADFLY noun
  1. Any dipterous insect of the family Oestridae, commonly known as botflies.
  2. A horsefly: any of various species of fly, of the family Tabanidae, noted for buzzing about animals and sucking their blood.
  3. One who upsets the status quo by posing upsetting or novel questions, or attempts to stimulate innovation by proving an irritant.
  4. One who merely irritates without making useful suggestions.
  5. A bloodsucker; a person who takes without giving back.

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