Cryptic crossword clue
Guerrillas of Baker Street commanded by Holmes 10

The most common and most likely answer to this crossword clue is the 10 letter word IRREGULARS

I
R
R
E
G
U
L
A
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S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IRREGULARS mean?

IRREGULARS noun
  1. A soldier who is not a member of an official military force and, often, does not follow regular army tactics
  2. One who does not regularly attend a venue

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