Cryptic crossword clue
Guinea pig: it comes out of a hole 4

The most common and most likely answer to this crossword clue is the 4 letter word CAVY

C
A
V
Y

Buddy explains!

The straight part
We know that "Guinea pig" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guinea pig = cavy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CAVY mean?

CAVY noun
  1. A tailless rodent of the family Caviidae and the genus Cavia, with short ears and larger than a hamster; the species Cavia porcellus is often kept as a pet.
  2. A rodent of any of several species within the family Caviidae.
  3. A living experimental subject.
  4. A professional company director, without time or real qualifications for the duties.
  5. A midshipman in the East India service; (by extension) a low-skilled or non-proficient seaman.

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