Cryptic crossword clue
Gullible people are crazy from top to bottom, like direction to follow 6

The most common and most likely answer to this crossword clue is the 6 letter word ADMASS

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Buddy explains!

The straight part
We know that "Gullible people" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gullible people = admass.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ADMASS mean?

ADMASS noun
  1. That part of society that is influenced by mass media advertising.

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