Cryptic crossword clue
Gun that’s very big is possible cause of blockage in passageway 8

The most common and most likely answer to this crossword clue is the 8 letter word STENOSIS

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does STENOSIS mean?

STENOSIS noun
  1. An abnormal narrowing or stricture in a blood vessel or other tubular organ
  2. A reduction in capacity (physical or mental)

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