Cryptic crossword clue
Gut feeling regularly affected by this 6

The most common and most likely answer to this crossword clue is the 6 letter word GLUTEN

I've seen this crossword clue in Independent
G
L
U
T
E
N


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The straight part
We know that "this" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case this = gluten.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GLUTEN mean?

GLUTEN noun
  1. Fibrin (formerly considered as one of the "animal humours").
  2. Any gluey, sticky substance.
  3. The major protein in cereal grains, especially wheat; responsible for the elasticity in dough and the structure in baked bread.
  4. A gluey, sticky mass of clay, bitumen etc.

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