The most common and most likely answer to this crossword clue is the 7 letter word DUODENA
I've seen this crossword clue in The Guardian
D
U
O
D
E
N
A
More clues leading to the result DUODENA
- Guts shown by couple turning and smothering last of fire
- Couple study American food processors
- Portions within poem penned by Auden, English cut and moved around
- Showing some guts, two-man team study what starts abuse
- Couple study article showing parts of intestines
- Couple on date in Parisian area showing some guts
Buddy explains!

The straight part
We know that "Guts" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guts = duodena.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DUODENA mean?
DUODENA noun- The first part of the small intestine, starting at the lower end of the stomach and extending to the jejunum.