The most common and most likely answer to this crossword clue is the 6 letter word HOMBRE
H
O
M
B
R
E
Buddy explains!
The straight part
We know that "Guy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guy = hombre.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HOMBRE mean?
HOMBRE noun- (in Spanish-speaking contexts) A man, a chap, a guy; especially a Hispanic or Spanish man.