Cryptic crossword clue
Guy takes barbituates at first, followed by cocaine and wine 6

The most common and most likely answer to this crossword clue is the 6 letter word MALBEC

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "wine" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case wine = malbec.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MALBEC mean?

MALBEC noun
  1. A variety of grape used in making red wine
  2. A red wine made chiefly from malbec grapes

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