The most common and most likely answer to this crossword clue is the 6 letter word TEASES
I've seen this crossword clue in The Daily Telegraph
T
E
A
S
E
S
More clues leading to the result TEASES
Buddy explains!

The straight part
We know that "Guys" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guys = teases.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TEASES mean?
TEASES noun- One who teases.
- A single act of teasing.
- One who deliberately arouses others (usually men) sexually with no intention of satisfying that arousal.