Cryptic crossword clue
Had onset of niggle in insides, laid up 5

The most common and most likely answer to this crossword clue is the 5 letter word STUNG

S
T
U
N
G


Buddy explains!

The straight part
We know that "Had" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case had = stung.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STUNG mean?

STUNG verb
  1. To hurt, usually by introducing poison or a sharp point, or both.
  2. (of an insect) To bite.
  3. (sometimes figurative) To hurt, to be in pain.
  4. To cause harm or pain to.

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