Cryptic crossword clue
Half of VIPs escaping in case, extremely sickening  6

The most common and most likely answer to this crossword clue is the 6 letter word VILEST

V
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L
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T

Buddy explains!

The straight part
We know that "extremely sickening" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case extremely sickening = vilest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VILEST mean?

VILEST adjective
  1. Morally low; base; despicable.
  2. Causing physical or mental repulsion; horrid.

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