Cryptic crossword clue
Hamlet’s last run in southern resort progressed well 6

The most common and most likely answer to this crossword clue is the 6 letter word THROVE

I've seen this crossword clue in The Guardian
T
H
R
O
V
E

Buddy explains!

The straight part
We know that "progressed well" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case progressed well = throve.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THROVE mean?

THROVE verb
  1. To grow or increase stature; to grow vigorously or luxuriantly, to flourish.
  2. To increase in wealth or success; to prosper, be profitable.

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