Cryptic crossword clue
Handles sliced white, a lady’s 6

The most common and most likely answer to this crossword clue is the 6 letter word WIELDS

I've seen this crossword clue in The Guardian
W
I
E
L
D
S

Buddy explains!

The straight part
We know that "Handles" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case handles = wields.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WIELDS mean?

WIELDS verb
  1. To command, rule over; to possess or own.
  2. To control, to guide or manage.
  3. To handle with skill and ease, especially a weapon or tool.
  4. To exercise (authority or influence) effectively.

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