Cryptic crossword clue
Handwriting being essentially lousy on instruction to pharmacist 10

The most common and most likely answer to this crossword clue is the 10 letter word MANUSCRIPT

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Buddy explains!

The straight part
We know that "Handwriting" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case handwriting = manuscript.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MANUSCRIPT mean?

MANUSCRIPT noun
  1. A book, composition or any other document, written by hand (or manually typewritten), not mechanically reproduced.
  2. A single, original copy of a book, article, composition etc, written by hand or even printed, submitted as original for (copy-editing and) reproductive publication.
MANUSCRIPT adjective
  1. Handwritten, or by extension manually typewritten, as opposed to being mechanically reproduced.

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