Cryptic crossword clue
Harbour on Guernsey, perhaps, set up for a global line 6

The most common and most likely answer to this crossword clue is the 6 letter word TROPIC

I've seen this crossword clue in The Guardian
T
R
O
P
I
C


Buddy explains!

The straight part
We know that "a global line" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a global line = tropic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.


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