The most common and most likely answer to this crossword clue is the 10 letter word HALF-TRUTH
I've seen this crossword clue in The Times
H
A
L
F
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T
R
U
T
H
More clues leading to the result HALF-TRUTH
Buddy explains!

The straight part
We know that "misleading remark" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case misleading remark = half-truth.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HALF-TRUTH mean?
HALF-TRUTH noun- A deceptive statement, especially one that is only partly true, is incomplete, misrepresents reality by telling part of the truth, or alters the time sequence of truths.