Cryptic crossword clue
Harry Lime in shady case, grinning 6

The most common and most likely answer to this crossword clue is the 6 letter word SMILEY

I've seen this crossword clue in The Daily Telegraph
S
M
I
L
E
Y


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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SMILEY mean?

SMILEY noun
  1. A simplified representation of a smiling face.
  2. A sequence of keyboard characters used to represent a happy mood, especially :) or :-) or other depiction of smiling.
  3. An improvised street weapon consisting of a length of chain with padlocks and other heavy objects affixed to one end.
  4. A roasted sheep's head.
  5. The type of piercing of the upper frenulum (upper lip).
SMILEY adjective
  1. Cheerful and happy; smiling.
  2. Having one's throat slit from side to side.

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