The most common and most likely answer to this crossword clue is the 6 letter word ENMITY
I've seen this crossword clue in Independent
E
N
M
I
T
Y
More clues leading to the result ENMITY
- Hostility in US Institute in Eastern US city
- Evil, not men's hatred
- Grave sin — eliminating men in hostile circumstances
- NY Times singularly spreading hatred
- Act arising out of extreme wickedness or out of antagonism
- Hate university in East NewYork
- It fed into heartless opposition and hatred
- Ill-will from being masculine, not tense
- Bulk discounting or causing antagonism
- Yankee after discharge receiving new antagonism
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ENMITY mean?
ENMITY noun- The quality of being an enemy; hostile or unfriendly disposition.
- A state or feeling of opposition, hostility, hatred or animosity.