The most common and most likely answer to this crossword clue is the 4 plus 3 plus 5 letter word FEAR THE WORST
F
E
A
R
T
H
E
W
O
R
S
T
More clues leading to the result FEAR THE WORST
Buddy explains!
The straight part
We know that "Have no hope of" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case have no hope of = fear the worst.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.