The most common and most likely answer to this crossword clue is the 8 letter word UNNERVED
I've seen this crossword clue in Financial Times
U
N
N
E
R
V
E
D
More clues leading to the result UNNERVED
Buddy explains!

The straight part
We know that "Having lost bottle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case having lost bottle = unnerved.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNNERVED mean?
UNNERVED verb- To deprive of nerve, force, or strength; to weaken; to enfeeble.
- To make somebody nervous, upset, alarm, shake the resolve of.
- Deprived of courage, strength, confidence, self-control, etc