Cryptic crossword clue
Having lost leader, get sealed somehow inside high school

The most common and most likely answer to this crossword clue is the 8 letter word HEADLESS

I've seen this crossword clue in Independent
H
E
A
D
L
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S
S

Buddy explains!

The straight part
We know that "Having lost leader" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case having lost leader = headless.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HEADLESS mean?

HEADLESS adjective
  1. Without a head; decapitated.
  2. Without leadership.
  3. (of a phrase or compound) Not having a head morpheme or word.
  4. Running without a graphical user interface; running without any attached output device (e.g., monitor) or input device (e.g., keyboard, mouse).
  5. (of beer) Without a head of foam.
  6. Heedless.

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