Cryptic crossword clue
Having no leader, manage sensibly with respect to employment 13

The most common and most likely answer to this crossword clue is the 13 letter word OPERATIONALLY

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Buddy explains!

The straight part
We know that "with respect to employment" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with respect to employment = operationally.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OPERATIONALLY mean?

OPERATIONALLY adverb
  1. In an operational manner; in accordance with an operation.

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