Cryptic crossword clue
Having total control on day work — colitis treated 12

The most common and most likely answer to this crossword clue is the 12 letter word MONOPOLISTIC

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Buddy explains!

The straight part
We know that "Having total control on" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case having total control on = monopolistic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MONOPOLISTIC mean?

MONOPOLISTIC adjective
  1. Acting in the manner of a monopoly.

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