Cryptic crossword clue
He and I twice wrestled with NHS Prozac complaint 13

The most common and most likely answer to this crossword clue is the 13 letter word SCHIZOPHRENIA

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "complaint" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case complaint = schizophrenia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SCHIZOPHRENIA mean?

SCHIZOPHRENIA noun
  1. A psychiatric diagnosis denoting a persistent, often chronic, mental illness characterised by abnormal perception, thinking, behavior and emotion, often marked by delusions.
  2. Any condition in which disparate or mutually exclusive activities coexist; a lack of decision between options.

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