Cryptic crossword clue
He cannot possibly work with tiny things

The most common and most likely answer to this crossword clue is the 8 letter word NANOTECH

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "work with tiny things" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case work with tiny things = nanotech.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NANOTECH mean?

NANOTECH noun
  1. The science and technology of creating nanoparticles and of manufacturing machines which have sizes within the range of nanometres.

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