Cryptic crossword clue
Head in miniature, wee like a mouse 6

The most common and most likely answer to this crossword clue is the 6 letter word MURINE

I've seen this crossword clue in The Guardian
M
U
R
I
N
E

Buddy explains!

The straight part
We know that "like a mouse" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case like a mouse = murine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MURINE mean?

MURINE noun
  1. Any murine mammal.
MURINE adjective
  1. Of, pertaining to, or characteristic of, the mouse, rat or (more generally) any mammal of the family Muridae.

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