Cryptic crossword clue
Head off big cat outside, after Jack’s put in danger

The most common and most likely answer to this crossword clue is the 11 letter word JEOPARDISED

I've seen this crossword clue in The Guardian
J
E
O
P
A
R
D
I
S
E
D

Buddy explains!

The straight part
We know that "put in danger" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case put in danger = jeopardised.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does JEOPARDISED mean?

JEOPARDISED verb
  1. To put in jeopardy, to threaten.

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