Cryptic crossword clue
Head off from English county to see Italian region 6

The most common and most likely answer to this crossword clue is the 6 letter word UMBRIA

I've seen this crossword clue in The Daily Telegraph
U
M
B
R
I
A


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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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