The most common and most likely answer to this crossword clue is the 6 letter word MENACE
M
E
N
A
C
E
More clues leading to the result MENACE
- Threat from people, one in a suit
- Expert pursuing soldiers in danger
- Headless chicken in club a nuisance
- Bully boys grown up perfect
- Threaten soldiers: excellent
- People; great threat
- People, great nuisance
- Threaten people with effective court action
- Not the first sign great service is under threat
- Danger: people shot in court
Buddy explains!

The straight part
We know that "a nuisance" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a nuisance = menace.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MENACE mean?
MENACE noun- A perceived threat or danger.
- The act of threatening.
- An annoying and bothersome person or thing.
- To make threats against (someone); to intimidate.
- To threaten (an evil to be inflicted).
- To endanger (someone or something); to imperil or jeopardize.